Invasive Pneumococcal Disease in a Population with Underlying Comorbidities

Invasive Pneumococcal Disease in a Population with Underlying Comorbidities

Vaccination, underlying comorbidities, and risk of invasive pneumococcal disease.

OBJECTIVES Children with underlying conditions remain at increased risk for invasive pneumococcal diseases (IPD). This study describes the epidemiology, serotype distribution, clinical presentations, and outcomes of IPD in children with and without comorbidity. METHODS Cases of childhood IPD in Massachusetts were identified via enhanced surveillance from 2002 through 2014. Demographic and cli...

Rates and costs of invasive pneumococcal disease and pneumonia in persons with underlying medical conditions

BACKGROUND The presence of certain underlying medical conditions is known to increase the risk of pneumococcal disease in persons of all ages and across a wide spectrum of conditions, as demonstrated in two recent evaluations. Corresponding estimates of attributable economic costs have not been well characterized. We thus undertook a retrospective evaluation to estimate rates and costs of pneum...

Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study

BACKGROUND Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). METHODS AND FINDINGS In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal seroty...

invasive pneumococcal disease; a serious and preventable infection